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Document type:
journal article 
Author(s):
Zimmermann, S; Kiefer, F; Prudenziati, M; Spiller, C; Hansen, J; Floss, T; Wurst, W; Minucci, S; Göttlicher, M 
Title:
Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice. 
Abstract:
Histone deacetylases (HDAC) reverse the acetylation of histone and nonhistone proteins and thereby modulate chromatin structure and function of nonhistone proteins. Many tumor cell lines and experimental tumors respond to HDAC inhibition. To assess the role of an individual HDAC isoenzyme in physiology and tumor development, HDAC2-mutant mice were generated from a gene trap embryonic stem cell clone. These mice express a catalytically inactive fusion protein of the NH(2)-terminal part of HDAC2 a...    »
 
Journal title abbreviation:
Cancer Res 
Year:
2007 
Journal volume:
67 
Journal issue:
19 
Pages contribution:
9047-54 
Language:
eng 
Print-ISSN:
0008-5472 
TUM Institution:
Institut für Toxikologie und Umwelthygiene