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Dokumenttyp:
journal article 
Autor(en):
Zimmermann, S; Kiefer, F; Prudenziati, M; Spiller, C; Hansen, J; Floss, T; Wurst, W; Minucci, S; Göttlicher, M 
Titel:
Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice. 
Abstract:
Histone deacetylases (HDAC) reverse the acetylation of histone and nonhistone proteins and thereby modulate chromatin structure and function of nonhistone proteins. Many tumor cell lines and experimental tumors respond to HDAC inhibition. To assess the role of an individual HDAC isoenzyme in physiology and tumor development, HDAC2-mutant mice were generated from a gene trap embryonic stem cell clone. These mice express a catalytically inactive fusion protein of the NH(2)-terminal part of HDAC2 a...    »
 
Zeitschriftentitel:
Cancer Res 
Jahr:
2007 
Band / Volume:
67 
Heft / Issue:
19 
Seitenangaben Beitrag:
9047-54 
Sprache:
eng 
Print-ISSN:
0008-5472 
TUM Einrichtung:
r Toxikologie und Umwelthygiene