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Document type:
journal article 
Author(s):
Thiermann, H; Kehe, K; Steinritz, D; Mikler, J; Hill, I; Zilker, T; Eyer, P; Worek, F 
Title:
Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds. 
Abstract:
Inhibition of acetylcholinesterase (AChE) is regarded as the primary toxic mechanism of organophosphorus compounds (OP). Therapeutic strategies are directed to antagonise overstimulation of muscarinic receptors with atropine and to reactivate inhibited AChE with oximes. Reactivation is crucial within the neuromuscular synapse, where atropine is ineffective, since peripheral neuromuscular block eventually leads to respiratory failure. Patients with OP intoxication have to be identified as early a...    »
 
Journal title abbreviation:
Arh Hig Rada Toksikol 
Year:
2007 
Journal volume:
58 
Journal issue:
Pages contribution:
359-66 
Language:
eng 
Print-ISSN:
0004-1254 
TUM Institution:
Toxikologische Abteilung