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Document type:
journal article 
Author(s):
Adam, M; Bayer, C; Henke, J; Grosu, A; Molls, M; Nieder, C 
Title:
Tirapazamine plus cisplatin and irradiation in a mouse model: improved tumor control at the cost of increased toxicity. 
Abstract:
PURPOSE: Tirapazamine (TPZ) reportedly enhances the tumor cell killing effect of cisplatin up to fivefold and it is an attractive drug for combination with radiotherapy. We evaluated the toxicity of a fractionated combined treatment. METHODS: Murine RIF-1 fibrosarcomas growing on the right hind foot of C3-H mice were used. Within 2 weeks, animals were treated with six i.p. injections of TPZ (43.2-172.8 mg/kg total), and/or cisplatin (24 mg/kg total) and ten fractions of 2 Gy to the tumor. All tr...    »
 
Journal title abbreviation:
J Cancer Res Clin Oncol 
Year:
2008 
Journal volume:
134 
Journal issue:
Pages contribution:
137-46 
Language:
eng 
Print-ISSN:
0171-5216 
TUM Institution:
r Strahlentherapie und Radiologische Onkologie