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Document type:
journal article 
Author(s):
Schmidt, H; Stonkute, A; Jüttner, R; Schäffer, S; Buttgereit, J; Feil, R; Hofmann, F; Rathjen, FG 
Title:
The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. 
Abstract:
Sensory axonal projections into the spinal cord display a highly stereotyped pattern of T- or Y-shaped axon bifurcation at the dorsal root entry zone (DREZ). Here, we provide evidence that embryonic mice with an inactive receptor guanylyl cyclase Npr2 or deficient for cyclic guanosine monophosphate-dependent protein kinase I (cGKI) lack the bifurcation of sensory axons at the DREZ, i.e., the ingrowing axon either turns rostrally or caudally. This bifurcation error is maintained to mature stages....    »
 
Journal title abbreviation:
J Cell Biol 
Year:
2007 
Journal volume:
179 
Journal issue:
Pages contribution:
331-40 
Language:
eng 
Print-ISSN:
0021-9525 
TUM Institution:
Institut für Pharmakologie und Toxikologie