Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Schmidt, H; Stonkute, A; Jüttner, R; Schäffer, S; Buttgereit, J; Feil, R; Hofmann, F; Rathjen, FG 
Titel:
The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. 
Abstract:
Sensory axonal projections into the spinal cord display a highly stereotyped pattern of T- or Y-shaped axon bifurcation at the dorsal root entry zone (DREZ). Here, we provide evidence that embryonic mice with an inactive receptor guanylyl cyclase Npr2 or deficient for cyclic guanosine monophosphate-dependent protein kinase I (cGKI) lack the bifurcation of sensory axons at the DREZ, i.e., the ingrowing axon either turns rostrally or caudally. This bifurcation error is maintained to mature stages....    »
 
Zeitschriftentitel:
J Cell Biol 
Jahr:
2007 
Band / Volume:
179 
Heft / Issue:
Seitenangaben Beitrag:
331-40 
Sprache:
eng 
Print-ISSN:
0021-9525 
TUM Einrichtung:
r Pharmakologie und Toxikologie