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Document type:
journal article 
Author(s):
Yfanti, C; Mengele, K; Gkazepis, A; Weirich, G; Giersig, C; Kuo, WL; Tang, WJ; Rosner, M; Schmitt, M 
Title:
Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues. 
Abstract:
Insulin-degrading enzyme (IDE, insulysin, insulinase; EC 3.4.22.11), a thiol metalloendopeptidase, is involved in intracellular degradation of insulin, thereby inhibiting its translocation and accumulation to the nucleus. Recently, protein expression of IDE has been demonstrated in the epithelial ducts of normal breast and breast cancer tissue. Utilizing four different antibodies generated against different epitopes of the IDE molecule, we performed Western blot analysis and immunohistochemical...    »
 
Journal title abbreviation:
Int J Mol Med 
Year:
2008 
Journal volume:
22 
Journal issue:
Pages contribution:
421-31 
Language:
eng 
Print-ISSN:
1107-3756 
TUM Institution:
Frauenklinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie