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Dokumenttyp:
journal article 
Autor(en):
Yfanti, C; Mengele, K; Gkazepis, A; Weirich, G; Giersig, C; Kuo, WL; Tang, WJ; Rosner, M; Schmitt, M 
Titel:
Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues. 
Abstract:
Insulin-degrading enzyme (IDE, insulysin, insulinase; EC 3.4.22.11), a thiol metalloendopeptidase, is involved in intracellular degradation of insulin, thereby inhibiting its translocation and accumulation to the nucleus. Recently, protein expression of IDE has been demonstrated in the epithelial ducts of normal breast and breast cancer tissue. Utilizing four different antibodies generated against different epitopes of the IDE molecule, we performed Western blot analysis and immunohistochemical...    »
 
Zeitschriftentitel:
Int J Mol Med 
Jahr:
2008 
Band / Volume:
22 
Heft / Issue:
Seitenangaben Beitrag:
421-31 
Sprache:
eng 
Print-ISSN:
1107-3756 
TUM Einrichtung:
Frauenklinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie