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Document type:
journal article 
Author(s):
Salaverria, I; Espinet, B; Carrió, A; Costa, D; Astier, L; Slotta-Huspenina, J; Quintanilla-Martinez, L; Fend, F; Solé, F; Colomer, D; Serrano, S; Miró, R; Beà, S; Campo, E 
Title:
Multiple recurrent chromosomal breakpoints in mantle cell lymphoma revealed by a combination of molecular cytogenetic techniques. 
Abstract:
Mantle cell lymphoma (MCL) is genetically characterized by 11q13 translocations leading to the overexpression of CCND1, and additional secondary genomic alterations that may be important in the progression of this disease. We have analyzed 22 MCL cases and 10 MCL cell lines using multicolor fluorescence in situ hybridization (M-FISH), FISH, and comparative genomic hybridization (CGH). The 19 cases with abnormal karyotype showed the t(11; 14)(q13; q32) translocation and, additionally, 89% of case...    »
 
Journal title abbreviation:
Genes Chromosomes Cancer 
Year:
2008 
Journal volume:
47 
Journal issue:
12 
Pages contribution:
1086-97 
Language:
eng 
Print-ISSN:
1045-2257 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie