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Document type:
Journal Article 
Author(s):
Beilhack, A; Schulz, S; Baker, J; Beilhack, GF; Nishimura, R; Baker, EM; Landan, G; Herman, EI; Butcher, EC; Contag, CH; Negrin, RS 
Title:
Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs. 
Abstract:
In acute graft-versus-host disease (aGVHD), donor T cells attack the recipient's gastrointestinal tract, liver, and skin. We hypothesized that blocking access to distinct lymphoid priming sites may alter the specific organ tropism and prevent aGVHD development. In support of this initial hypothesis, we found that different secondary lymphoid organs (SLOs) imprint distinct homing receptor phenotypes on evolving alloreactive effector T cells in vivo. Yet preventing T-cell entry to specific SLOs th...    »
 
Journal title abbreviation:
Blood 
Year:
2008 
Journal volume:
111 
Journal issue:
Pages contribution:
2919-28 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie