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Dokumenttyp:
journal article 
Autor(en):
Beilhack, A; Schulz, S; Baker, J; Beilhack, GF; Nishimura, R; Baker, EM; Landan, G; Herman, EI; Butcher, EC; Contag, CH; Negrin, RS 
Titel:
Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs. 
Abstract:
In acute graft-versus-host disease (aGVHD), donor T cells attack the recipient's gastrointestinal tract, liver, and skin. We hypothesized that blocking access to distinct lymphoid priming sites may alter the specific organ tropism and prevent aGVHD development. In support of this initial hypothesis, we found that different secondary lymphoid organs (SLOs) imprint distinct homing receptor phenotypes on evolving alloreactive effector T cells in vivo. Yet preventing T-cell entry to specific SLOs th...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2008 
Band / Volume:
111 
Heft / Issue:
Seitenangaben Beitrag:
2919-28 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie