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Document type:
journal article 
Author(s):
Slotta-Huspenina, J; Koch, I; Richter, M; Bink, K; Kremer, M; Specht, K; Krugmann, J; Quintanilla-Martinez, L; Fend, F 
Title:
Cyclin D1 positive multiple myeloma: Predominance of the short, 3'UTR-deficient transcript is associated with high cyclin D1 mRNA levels in cases with t(11; 14) translocation, but does not correlate with proliferation rate or genomic deletions. 
Abstract:
Multiple myeloma (MM) frequently shows overexpression of cyclin D1, either due to a t(11; 14)(q13; q32) translocation, or in association with polysomy 11. The predominant expression of a cyclin D1 mRNA isoform lacking the 3'-untranslated region (Delta3'UTR) is associated with higher total cyclin D1 mRNA levels, increased proliferation and poor prognosis in mantle cell lymphoma, and can be caused by genetic alterations of the 3'UTR region. The role of this cyclin D1 isoform in MM is unknown. We t...    »
 
Journal title abbreviation:
Leuk Res 
Year:
2008 
Journal volume:
32 
Journal issue:
Pages contribution:
79-88 
Language:
eng 
Print-ISSN:
0145-2126 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie