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Document type:
journal article 
Author(s):
Ruhe, JE; Streit, S; Hart, S; Wong, CH; Specht, K; Knyazev, P; Knyazeva, T; Tay, LS; Loo, HL; Foo, P; Wong, W; Pok, S; Lim, SJ; Ong, H; Luo, M; Ho, HK; Peng, K; Lee, TC; Bezler, M; Mann, C; Gaertner, S; Hoefler, H; Iacobelli, S; Peter, S; Tay, A; Brenner, S; Venkatesh, B; Ullrich, A 
Title:
Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines. 
Abstract:
Protein tyrosine kinases (PTKs) play a critical role in the manifestation of cancer cell properties, and respective signaling mechanisms have been studied extensively on immortalized tumor cells. To characterize and analyze commonly used cancer cell lines with regard to variations in the primary structure of all expressed PTKs, we conducted a cDNA-based sequence analysis of the entire tyrosine kinase transcriptome of 254 established tumor cell lines. The profiles of cell line intrinsic PTK trans...    »
 
Journal title abbreviation:
Cancer Res 
Year:
2007 
Journal volume:
67 
Journal issue:
23 
Pages contribution:
11368-76 
Language:
eng 
Print-ISSN:
0008-5472 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie