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Dokumenttyp:
journal article 
Autor(en):
Schlumberger, MC; Käppeli, R; Wetter, M; Müller, AJ; Misselwitz, B; Dilling, S; Kremer, M; Hardt, WD 
Titel:
Two newly identified SipA domains (F1, F2) steer effector protein localization and contribute to Salmonella host cell manipulation. 
Abstract:
Salmonella Typhimurium causes bacterial enterocolitis. The type III secretion system (TTSS)-1 is a key virulence determinant of S. Typhimurium mediating host cell invasion and acute enterocolitis. The TTSS-1 effector protein SipA is transported into host cells, accumulates in characteristic foci at the bacteria-host cell interface, manipulates signalling and affects virulence. Two functional domains of SipA have previously been characterized: The N-terminal SipA region (amino acids 1-105) mediat...    »
 
Zeitschriftentitel:
Mol Microbiol 
Jahr:
2007 
Band / Volume:
65 
Heft / Issue:
Seitenangaben Beitrag:
741-60 
Sprache:
eng 
Print-ISSN:
0950-382X 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie