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Document type:
journal article 
Author(s):
Mateus, AR; Seruca, R; Machado, JC; Keller, G; Oliveira, MJ; Suriano, G; Luber, B 
Title:
EGFR regulates RhoA-GTP dependent cell motility in E-cadherin mutant cells. 
Abstract:
Gastric cancer associated E-cadherin germline missense mutations lead to significant functional consequences, in both the structural and signalling properties of the protein. In this study, we have characterized the effect of four E-cadherin germline missense mutations (T340A, A634V, P799R and V832M) in the interaction with the epidermal growth factor receptor (EGFR). We challenged the hypothesis that E-cadherin mutations perturb its ability to bind to EGFR, leading to constitutional activation...    »
 
Journal title abbreviation:
Hum Mol Genet 
Year:
2007 
Journal volume:
16 
Journal issue:
13 
Pages contribution:
1639-47 
Language:
eng 
Print-ISSN:
0964-6906 
TUM Institution:
r Allgemeine Pathologie und pathologische Anatomie