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Dokumenttyp:
journal article 
Autor(en):
Bettstetter, M; Dechant, S; Ruemmele, P; Grabowski, M; Keller, G; Holinski-Feder, E; Hartmann, A; Hofstaedter, F; Dietmaier, W 
Titel:
Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR. 
Abstract:
PURPOSE: Promoter hypermethylation occurs frequently in tumors and leads to silencing of tumor-relevant genes like tumor suppressor genes. In a subset of sporadic colorectal cancers (CRC), inactivation of the mismatch repair gene MLH1 due to promoter methylation causes high level of microsatellite instability (MSI-H). MSI-H is also a hallmark of hereditary nonpolyposis colorectal cancer (HNPCC) in which mismatch repair inactivation results from germ-line mutations. For differentiation of sporadi...    »
 
Zeitschriftentitel:
Clin Cancer Res 
Jahr:
2007 
Band / Volume:
13 
Heft / Issue:
11 
Seitenangaben Beitrag:
3221-8 
Sprache:
eng 
Print-ISSN:
1078-0432 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie