User: Guest  Login
Document type:
journal article 
Author(s):
Bettstetter, M; Dechant, S; Ruemmele, P; Grabowski, M; Keller, G; Holinski-Feder, E; Hartmann, A; Hofstaedter, F; Dietmaier, W 
Title:
Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR. 
Abstract:
PURPOSE: Promoter hypermethylation occurs frequently in tumors and leads to silencing of tumor-relevant genes like tumor suppressor genes. In a subset of sporadic colorectal cancers (CRC), inactivation of the mismatch repair gene MLH1 due to promoter methylation causes high level of microsatellite instability (MSI-H). MSI-H is also a hallmark of hereditary nonpolyposis colorectal cancer (HNPCC) in which mismatch repair inactivation results from germ-line mutations. For differentiation of sporadi...    »
 
Journal title abbreviation:
Clin Cancer Res 
Year:
2007 
Journal volume:
13 
Journal issue:
11 
Pages contribution:
3221-8 
Language:
eng 
Print-ISSN:
1078-0432 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie