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Document type:
journal article 
Author(s):
Dietel, M; Ellis, IO; Höfler, H; Kreipe, H; Moch, H; Dankof, A; Kölble, K; Kristiansen, G 
Title:
Comparison of automated silver enhanced in situ hybridisation (SISH) and fluorescence ISH (FISH) for the validation of HER2 gene status in breast carcinoma according to the guidelines of the American Society of Clinical Oncology and the College of America 
Abstract:
HER2 is an important tumour marker in breast cancer. However, there is controversy regarding which method reliably measures HER2 status. This study evaluates the concordance between HER2 gene amplification in invasive breast cancer determined by fluorescence in situ hybridisation (FISH) and a new silver enhanced in situ hybridisation (SISH) technique. Ninety-nine cases were analysed by direct-labelled manual FISH (PathVysion(R), Abbott/Vysis) and bright field automated SISH (INFORM(R), Ventana)....    »
 
Journal title abbreviation:
Virchows Arch 
Year:
2007 
Journal volume:
451 
Journal issue:
Pages contribution:
19-25 
Language:
eng 
Print-ISSN:
0945-6317 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie