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Document type:
journal article 
Author(s):
Pellegata, NS; Quintanilla-Martinez, L; Keller, G; Liyanarachchi, S; Höfler, H; Atkinson, MJ; Fend, F 
Title:
Human pheochromocytomas show reduced p27Kip1 expression that is not associated with somatic gene mutations and rarely with deletions. 
Abstract:
Pheochromocytomas are neuroendocrine tumors arising in the neural crest-derived chromaffin cells of the adrenal gland or in extra-adrenal sympathetic ganglia (paragangliomas). In a rat model of multiple endocrine neoplasia (MEN), absence of functional p27Kip1 protein predisposes to pheochromocytoma and paraganglioma development. As no data is available regarding the involvement of p27Kip1 in human pheochromocytoma and/or paraganglioma, we set out to determine the expression pattern of p27Kip1 in...    »
 
Journal title abbreviation:
Virchows Arch 
Year:
2007 
Journal volume:
451 
Journal issue:
Pages contribution:
37-46 
Language:
eng 
Print-ISSN:
0945-6317 
TUM Institution:
r Allgemeine Pathologie und pathologische Anatomie