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Dokumenttyp:
journal article 
Autor(en):
Anlauf, M; Perren, A; Henopp, T; Rudolf, T; Garbrecht, N; Schmitt, A; Raffel, A; Gimm, O; Weihe, E; Knoefel, WT; Dralle, H; Heitz, PU; Komminoth, P; Klöppel, G 
Titel:
Allelic deletion of the MEN1 gene in duodenal gastrin and somatostatin cell neoplasms and their precursor lesions. 
Abstract:
BACKGROUND: Patients with a multiple endocrine neoplasia type 1 (MEN1)-associated Zollinger-Ellison syndrome (ZES) show multifocal duodenal gastrinomas and precursor lesions. AIMS: To test these lesions for loss of heterozygosity (LOH) of the MEN1 gene locus on chromosome 11q13, and to investigate whether the MEN1-related endocrine cell changes also involved somatostatin cells. Material and METHODS: Tissue specimens from six patients with MEN1 and ZES were analysed by immunohistochemistry and im...    »
 
Zeitschriftentitel:
Gut 
Jahr:
2007 
Band / Volume:
56 
Heft / Issue:
Seitenangaben Beitrag:
637-44 
Sprache:
eng 
Print-ISSN:
0017-5749 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie