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Dokumenttyp:
journal article 
Autor(en):
Perren, A; Anlauf, M; Henopp, T; Rudolph, T; Schmitt, A; Raffel, A; Gimm, O; Weihe, E; Knoefel, WT; Dralle, H; Heitz, PU; Komminoth, P; Klöppel, G 
Titel:
Multiple Endocrine Neoplasia Type 1 (MEN1): Loss of One MEN1 Allele in Tumors and Monohormonal Endocrine Cell Clusters But Not in Islet Hyperplasia of the Pancreas. 
Abstract:
Context: The occurrence of multiple small pancreatic endocrine tumors in patients suffering from multiple endocrine neoplasia type 1 (MEN1) represents a unique possibility to study early neoplasms and their potential precursor lesions. To date, it is unknown whether small islet-like endocrine cell clusters found in MEN1 patients are neoplastic or rather hyperplastic. It is also unclear whether microadenomas develop from islets. Design: We hypothesized that monohormonal endocrine cell clusters ob...    »
 
Zeitschriftentitel:
J Clin Endocrinol Metab 
Jahr:
2007 
Band / Volume:
92 
Heft / Issue:
Seitenangaben Beitrag:
1118-28 
Sprache:
eng 
Print-ISSN:
0021-972X 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie