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Dokumenttyp:
journal article 
Autor(en):
Hoberg, M; Rudert, M; Pap, T; Klein, G; Gay, S; Aicher, WK 
Titel:
Attachment to laminin-111 facilitates transforming growth factor beta-induced expression of matrix metalloproteinase-3 in synovial fibroblasts. 
Abstract:
BACKGROUND: In the synovial membrane of patients with rheumatoid arthritis (RA), a strong expression of laminins and matrix degrading proteases was reported. Aim: To investigate the regulation of matrix metalloproteinases (MMPs) in synovial fibroblasts (SFs) of patients with osteoarthritis (OA) and RA by attachment to laminin-1 (LM-111) and in the presence or absence of costimulatory signals provided by transforming growth factor beta (TGFbeta). METHODS: SFs were seeded in laminin-coated flasks...    »
 
Zeitschriftentitel:
Ann Rheum Dis 
Jahr:
2007 
Band / Volume:
66 
Heft / Issue:
Seitenangaben Beitrag:
446-51 
Sprache:
eng 
Print-ISSN:
0003-4967 
TUM Einrichtung:
dische Klinik und Poliklinik