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Document type:
journal article 
Author(s):
Willhauck, MJ; Sharif Samani, BR; Gildehaus, FJ; Wolf, I; Senekowitsch-Schmidtke, R; Stark, HJ; Göke, B; Morris, JC; Spitzweg, C 
Title:
Application of 188rhenium as an alternative radionuclide for treatment of prostate cancer after tumor-specific sodium iodide symporter gene expression. 
Abstract:
CONTEXT: We reported recently the induction of iodide accumulation in prostate cancer cells (LNCaP) by prostate-specific antigen promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)iodine ((131)I). These data demonstrated the potential of the NIS gene as a novel therapeutic gene, although in some extrathyroidal tumors, therapeutic efficacy may be limited by rapid iodide efflux due to a lack of iodide organification. OBJECTIVE: In the c...    »
 
Journal title abbreviation:
J Clin Endocrinol Metab 
Year:
2007 
Journal volume:
92 
Journal issue:
11 
Pages contribution:
4451-8 
Language:
eng 
Print-ISSN:
0021-972X 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik