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Document type:
Journal Article 
Author(s):
Prante, O; Einsiedel, J; Haubner, R; Gmeiner, P; Wester, HJ; Kuwert, T; Maschauer, S 
Title:
3,4,6-Tri-O-acetyl-2-deoxy-2-[(18)F]fluoroglucopyranosyl Phenylthiosulfonate: A Thiol-Reactive Agent for the Chemoselective (18)F-Glycosylation of Peptides. 
Abstract:
3,4,5-Tri-O-acetyl-2-[18F]fluoro-2-deoxy-d-glucopyranosyl 1-phenylthiosulfonate (Ac3-[18F]FGlc-PTS) was developed as a thiol-reactive labeling reagent for the site-specific 18F-glycosylation of peptides. Taking advantage of highly accessible 1,3,4,6-tetra-O-acetyl-2-deoxy-2-[18F]fluoroglucopyranose, a three-step radiochemical pathway was investigated and optimized, providing Ac3-[18F]FGlc-PTS in a radiochemical yield of about 33% in 90 min (decay-corrected and based on starting [18F]fluoride). A...    »
 
Journal title abbreviation:
Bioconjug Chem 
Year:
2007 
Journal volume:
18 
Journal issue:
Pages contribution:
254-262 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1043-1802 
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin