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Document type:
journal article 
Author(s):
Neumaier, B; Deisenhofer, S; Fürst, D; von Arnim, CA; Thees, S; Buck, AK; Glatting, G; Landwehrmeyer, GB; Krause, BJ; Müller, HD; Sommer, C; Reske, SN; Mottaghy, FM 
Title:
Radiosynthesis and evaluation of [11C]BTA-1 and [11C]3'-Me-BTA-1 as potential radiotracers for in vivo imaging of beta-amyloid plaques. 
Abstract:
AIM: To evaluate the in vitro and in vivo characteristics of [N-methyl-(11)C]2-(4'-(methylaminophenyl)-benzothiazole ([(11)C]BTA-1) as well as [N-methyl-(11)C]2-(3'-methyl-4'-(methylamino)phenyl)-benzothiazole ([(11)C]3'-Me-BTA-1) as diagnostic markers of amyloid-beta (Abeta) in Alzheimer's disease (AD). MATERIAL, METHODS: Brain uptake and clearance was determined in wild-type mice. Binding affinities (K(i)) of [(11)C]BTA-1 and [(11)C]3'-Me-BTA-1 for aggregated Abeta(1-40) fibrils were assessed....    »
 
Journal title abbreviation:
Nuklearmedizin 
Year:
2007 
Journal volume:
46 
Journal issue:
Pages contribution:
271-80 
Language:
eng 
Print-ISSN:
0029-5566 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik