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Document type:
journal article 
Author(s):
Vogg, AT; Buck, AK; Schmid, M; Neumaier, B; Wczasek, K; Zlatopolskiy, BD; Reske, SN 
Title:
Synthesis and biodistribution of 3'-fluoro-5-[(131)I]iodo-2'-deoxyuridine: a comparative study of [(131)I]FLIdU and [(18)F]FLT. 
Abstract:
The radioiodinated 3'-fluorothymidine (FLT) analogue 3'-fluoro-5-[(131)I]iodo-2'-deoxyuridine ([(131)I]FLIdU) was synthesized, with iodine mimicking the methyl group of pyrimidine. [(131)I]FLIdU was accessible by direct electrophilic iodination using Iodogen as oxidant. Optimized amounts of the oxidant allowed radiochemical yields of about 70% after a reaction time of 10 min in an aqueous buffer medium at 90 degrees C. The uptake of [(131)I]FLIdU in a DoHH2 leukemia xenograft mouse model and in...    »
 
Journal title abbreviation:
Nucl Med Biol 
Year:
2007 
Journal volume:
34 
Journal issue:
Pages contribution:
273-81 
Language:
eng 
Print-ISSN:
0969-8051 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik