User: Guest  Login
Document type:
journal article 
Author(s):
Gaertner, FC; Luxenhofer, R; Blechert, B; Jordan, R; Essler, M 
Title:
Synthesis, biodistribution and excretion of radiolabeled poly(2-alkyl-2-oxazoline)s. 
Abstract:
Here we report on the preparation of well defined water-soluble poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline) terminally equipped with a chelator (N,N',N'',N'''-tetraazacylododecane-1,4,7,10-tetraacetic acid (DOTA)) for radionuclide labeling. The tissue distribution and excretion of (111)In-labeled poly(2-alkyl-2-oxazoline)s were studied in mice. We found that the hydrophilic polymers do not accumulate in tissues and are rapidly cleared from the blood pool, predominantly by glomerular...    »
 
Journal title abbreviation:
J Control Release 
Year:
2007 
Journal volume:
119 
Journal issue:
Pages contribution:
291-300 
Language:
eng 
Print-ISSN:
0168-3659 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik