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Dokumenttyp:
journal article 
Autor(en):
Gaertner, FC; Luxenhofer, R; Blechert, B; Jordan, R; Essler, M 
Titel:
Synthesis, biodistribution and excretion of radiolabeled poly(2-alkyl-2-oxazoline)s. 
Abstract:
Here we report on the preparation of well defined water-soluble poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline) terminally equipped with a chelator (N,N',N'',N'''-tetraazacylododecane-1,4,7,10-tetraacetic acid (DOTA)) for radionuclide labeling. The tissue distribution and excretion of (111)In-labeled poly(2-alkyl-2-oxazoline)s were studied in mice. We found that the hydrophilic polymers do not accumulate in tissues and are rapidly cleared from the blood pool, predominantly by glomerular...    »
 
Zeitschriftentitel:
J Control Release 
Jahr:
2007 
Band / Volume:
119 
Heft / Issue:
Seitenangaben Beitrag:
291-300 
Sprache:
eng 
Print-ISSN:
0168-3659 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik