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Document type:
journal article 
Author(s):
Seidl, C; Port, M; Gilbertz, KP; Morgenstern, A; Bruchertseifer, F; Schwaiger, M; Röper, B; Senekowitsch-Schmidtke, R; Abend, M 
Title:
213Bi-induced death of HSC45-M2 gastric cancer cells is characterized by G2 arrest and up-regulation of genes known to prevent apoptosis but induce necrosis and mitotic catastrophe. 
Abstract:
Tumor cells are efficiently killed after incubation with alpha-emitter immunoconjugates targeting tumor-specific antigens. Therefore, application of alpha-emitter immunoconjugates is a promising therapeutic option for treatment of carcinomas that are characterized by dissemination of single tumor cells in the peritoneum like ovarian cancer or gastric cancer. In diffuse-type gastric cancer, 10% of patients express mutant d9-E-cadherin on the surface of tumor cells that is targeted by the monoclon...    »
 
Journal title abbreviation:
Mol Cancer Ther 
Year:
2007 
Journal volume:
Journal issue:
Pages contribution:
2346-59 
Language:
eng 
Print-ISSN:
1535-7163 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik; r Strahlentherapie und Radiologische Onkologie