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Document type:
journal article 
Author(s):
Nessler, S; Boretius, S; Stadelmann, C; Bittner, A; Merkler, D; Hartung, HP; Michaelis, T; Brück, W; Frahm, J; Sommer, N; Hemmer, B 
Title:
Early MRI changes in a mouse model of multiple sclerosis are predictive of severe inflammatory tissue damage. 
Abstract:
MRI is routinely used for in vivo detection of multiple sclerosis (MS) lesions. Histopathological correlates of MRI signal alterations are still poorly defined. In the present study, we describe a mouse model of MS presenting with inflammatory brain lesions. During the acute disease phase, two independent lesion patterns were identified by T1- and T2-weighted high-resolution 3D MRI: lesions with reduced signal intensity on both T1- and T2-weighted images (type A) and lesions with slightly reduce...    »
 
Journal title abbreviation:
Brain 
Year:
2007 
Journal volume:
130 
Journal issue:
Pt 8 
Pages contribution:
2186-98 
Language:
eng 
Print-ISSN:
0006-8950 
TUM Institution:
Neurologische Klinik und Poliklinik