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Document type:
journal article 
Author(s):
Baumann, M; Hermans, JJ; Janssen, BJ; Peutz-Kootstra, C; Witzke, O; Heemann, U; Smits, JF; Boudier, HA 
Title:
Transient prehypertensive treatment in spontaneously hypertensive rats: a comparison of spironolactone and losartan regarding long-term blood pressure and target organ damage. 
Abstract:
OBJECTIVE: We previously demonstrated that when the renin-angiotensin system (RAS) is transiently blocked by an angiotensin receptor blocker (ARB) in young spontaneously hypertensive rats (SHR), this results in a prolonged blood pressure decrease and protection against target organ damage. Aldosterone is an essential hormone in the RAS, and contributes to pathologic remodeling. Thus, part of the protective effects of the ARB may be due to inhibition of aldosterone-mediated effects. To test this...    »
 
Journal title abbreviation:
J Hypertens 
Year:
2007 
Journal volume:
25 
Journal issue:
12 
Pages contribution:
2504-11 
Language:
eng 
Print-ISSN:
0263-6352 
TUM Institution:
r Nephrologie