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Document type:
journal article 
Author(s):
Schleicher, U; Liese, J; Knippertz, I; Kurzmann, C; Hesse, A; Heit, A; Fischer, JA; Weiss, S; Kalinke, U; Kunz, S; Bogdan, C 
Title:
NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. 
Abstract:
Natural killer (NK) cells are sentinel components of the innate response to pathogens, but the cell types, pathogen recognition receptors, and cytokines required for their activation in vivo are poorly defined. Here, we investigated the role of plasmacytoid dendritic cells (pDCs), myeloid DCs (mDCs), Toll-like receptors (TLRs), and of NK cell stimulatory cytokines for the induction of an NK cell response to the protozoan parasite Leishmania infantum. In vitro, pDCs did not endocytose Leishmania...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2007 
Journal volume:
204 
Journal issue:
Pages contribution:
893-906 
Language:
eng 
Print-ISSN:
0022-1007 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene