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Document type:
journal article 
Author(s):
Wiethe, C; Schiemann, M; Busch, D; Haeberle, L; Kopf, M; Schuler, G; Lutz, MB 
Title:
Interdependency of MHC class II/self-peptide and CD1d/self-glycolipid presentation by TNF-matured dendritic cells for protection from autoimmunity. 
Abstract:
Dendritic cells (DC) are key regulators of T cell immunity and tolerance. NKT cells are well-known enhancers of Th differentiation and regulatory T cell function. However, the nature of the DC directing T and NKT cell activation and polarization as well as the role of the respective CD1d Ags presented is still unclear. In this study, we show that peptide-specific CD4(+)IL-10(+) T cell-mediated full experimental autoimmune encephalomyelitis (EAE) protection by TNF-treated semimatured DCs was depe...    »
 
Journal title abbreviation:
J Immunol 
Year:
2007 
Journal volume:
178 
Journal issue:
Pages contribution:
4908-16 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene