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Dokumenttyp:
journal article 
Autor(en):
Wiethe, C; Schiemann, M; Busch, D; Haeberle, L; Kopf, M; Schuler, G; Lutz, MB 
Titel:
Interdependency of MHC class II/self-peptide and CD1d/self-glycolipid presentation by TNF-matured dendritic cells for protection from autoimmunity. 
Abstract:
Dendritic cells (DC) are key regulators of T cell immunity and tolerance. NKT cells are well-known enhancers of Th differentiation and regulatory T cell function. However, the nature of the DC directing T and NKT cell activation and polarization as well as the role of the respective CD1d Ags presented is still unclear. In this study, we show that peptide-specific CD4(+)IL-10(+) T cell-mediated full experimental autoimmune encephalomyelitis (EAE) protection by TNF-treated semimatured DCs was depe...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2007 
Band / Volume:
178 
Heft / Issue:
Seitenangaben Beitrag:
4908-16 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene