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Document type:
journal article 
Author(s):
Lahl, K; Loddenkemper, C; Drouin, C; Freyer, J; Arnason, J; Eberl, G; Hamann, A; Wagner, H; Huehn, J; Sparwasser, T 
Title:
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. 
Abstract:
The scurfy mutant mouse strain suffers from a fatal lymphoproliferative disease leading to early death within 3-4 wk of age. A frame-shift mutation of the forkhead box transcription factor Foxp3 has been identified as the molecular cause of this multiorgan autoimmune disease. Foxp3 is a central control element in the development and function of regulatory T cells (T reg cells), which are necessary for the maintenance of self-tolerance. However, it is unclear whether dysfunction or a lack of T re...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2007 
Journal volume:
204 
Journal issue:
Pages contribution:
57-63 
Language:
eng 
Print-ISSN:
0022-1007 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene