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Dokumenttyp:
journal article 
Autor(en):
Merx, S; Neumaier, M; Wagner, H; Kirschning, CJ; Ahmad-Nejad, P 
Titel:
Characterization and investigation of single nucleotide polymorphisms and a novel TLR2 mutation in the human TLR2 gene. 
Abstract:
In the innate immune system, TLR2 plays a central role for the response to a wide variety of microbial and endogenous danger signals. A considerable number of genetic polymorphisms within the human TLR2 gene have been reported in non-coding and coding sequences. Except for the Arg753Gln variant, however, their clinical relevance is unclear and the assessment of the effects of amino acid substitutions on receptor function is lacking. In the present study, we have characterized all known single nu...    »
 
Zeitschriftentitel:
Hum Mol Genet 
Jahr:
2007 
Band / Volume:
16 
Heft / Issue:
10 
Seitenangaben Beitrag:
1225-32 
Sprache:
eng 
Print-ISSN:
0964-6906 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene