User: Guest  Login
Document type:
journal article 
Author(s):
Geisel, J; Kahl, F; Müller, M; Wagner, H; Kirschning, CJ; Autenrieth, IB; Frick, JS 
Title:
IL-6 and maturation govern TLR2 and TLR4 induced TLR agonist tolerance and cross-tolerance in dendritic cells. 
Abstract:
Stimulation of naive mouse dendritic cells (DC) with LPS or Pam(3)CSK(4) (P3C) induces production of TNF-alpha via TLR4- or TLR2-signaling. Although tolerance in macrophages has been studied in detail, we investigated the role of TLR agonist concentration and IL-6 for tolerance in DC. P3C- or LPS-primed DC were nonresponsive to P3C or LPS restimulation in terms of TNF-alpha but not IL-6 production. The mechanisms involved in tolerance were dependent on the concentration of the TLR ligand used fo...    »
 
Journal title abbreviation:
J Immunol 
Year:
2007 
Journal volume:
179 
Journal issue:
Pages contribution:
5811-8 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene