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Dokumenttyp:
journal article 
Autor(en):
Rubio-Aliaga, I; Soewarto, D; Wagner, S; Klaften, M; Fuchs, H; Kalaydjiev, S; Busch, DH; Klempt, M; Rathkolb, B; Wolf, E; Abe, K; Zeiser, S; Przemeck, GK; Beckers, J; de Angelis, MH 
Titel:
A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse. 
Abstract:
The Notch signaling pathway is an evolutionarily conserved transduction pathway involved in embryonic patterning and regulation of cell fates during development. Recent studies have demonstrated that this pathway is integral to a complex system of interactions, which are also involved in distinct human diseases. Delta1 is one of the known ligands of the Notch receptors. Mice homozygous for a loss-of-function allele of the Delta1 gene Dll1(lacZ/lacZ) die during embryonic development. Here, we pre...    »
 
Zeitschriftentitel:
Genetics 
Jahr:
2007 
Band / Volume:
175 
Heft / Issue:
Seitenangaben Beitrag:
1451-63 
Sprache:
eng 
Print-ISSN:
0016-6731 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene