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Document type:
journal article 
Author(s):
Koedel, U; Merbt, UM; Schmidt, C; Angele, B; Popp, B; Wagner, H; Pfister, HW; Kirschning, CJ 
Title:
Acute brain injury triggers MyD88-dependent, TLR2/4-independent inflammatory responses. 
Abstract:
Endogenous molecules released from disrupted cells and extracellular matrix degradation products activate Toll-like receptors (TLRs) and, thus, might contribute to immune activation after tissue injury. Here, we show that aseptic, cold-induced cortical injury triggered an acute immune response that involves increased production of multiple cytokines/chemokines accompanied by neutrophil recruitment to the lesion site. We observed selective reductions in injury-induced cytokine/chemokine expressio...    »
 
Journal title abbreviation:
Am J Pathol 
Year:
2007 
Journal volume:
171 
Journal issue:
Pages contribution:
200-13 
Language:
eng 
Print-ISSN:
0002-9440 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene