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Document type:
journal article 
Author(s):
Zantl, N; Weirich, G; Zall, H; Seiffert, BM; Fischer, SF; Kirschnek, S; Hartmann, C; Fritsch, RM; Gillissen, B; Daniel, PT; Häcker, G 
Title:
Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance. 
Abstract:
Renal cell carcinoma (RCC) is resistant to chemotherapy, and this resistance is mirrored by a high apoptosis resistance of many RCC lines in vitro. Here, we report the loss of the pro-apoptotic BH3-only protein Bim in a large part of clinical RCC cases and provide evidence for a functional relevance of this loss. Immunohistochemistry of clear cell renal cell carcinoma cases and corresponding normal kidney showed strong Bim reactivity in renal tubules of all cases but loss of Bim in 35 of 45 RCC...    »
 
Journal title abbreviation:
Oncogene 
Year:
2007 
Journal volume:
26 
Journal issue:
49 
Pages contribution:
7038-48 
Language:
eng 
Print-ISSN:
0950-9232 
TUM Institution:
Urologische Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie; r Medizinische Mikrobiologie, Immunologie und Hygiene