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Document type:
journal article 
Author(s):
Grunewald, TG; Kammerer, U; Winkler, C; Schindler, D; Sickmann, A; Honig, A; Butt, E 
Title:
Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation. 
Abstract:
LIM and SH3 protein 1 (LASP-1), initially identified from human breast cancer, is a specific focal adhesion protein involved in cell proliferation and migration. In the present work, we analysed the effect of LASP-1 on biology and function of human ovarian cancer cell line SKOV-3 using small interfering RNA technique (siRNA).Transfection with LASP-1-specific siRNA resulted in a reduced protein level of LASP-1 in SKOV-3 cells. The siRNA-treated cells were arrested in G(2)/M phase of the cell cycl...    »
 
Journal title abbreviation:
Br J Cancer 
Year:
2007 
Journal volume:
96 
Journal issue:
Pages contribution:
296-305 
Language:
eng 
Print-ISSN:
0007-0920 
TUM Institution:
Kinderklinik und Poliklinik