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Dokumenttyp:
journal article 
Autor(en):
Qing, M; Quing, M; Görlach, A; Schumacher, K; Wöltje, M; Vazquez-Jimenez, JF; Hess, J; Seghaye, MC 
Titel:
The hypoxia-inducible factor HIF-1 promotes intramyocardial expression of VEGF in infants with congenital cardiac defects. 
Abstract:
OBJECTIVES : The response to hypoxia is primarily mediated by the transcription factor hypoxia-inducible factor-1 (HIF-1) which leads to the induction of a variety of adaptive gene products including vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS). This study was designed to test the hypothesis that HIF-1 and its target genes would be upregulated in the ventricular myocardium of infants with cyanotic congenital cardiac defects. METHODS : 14 infants with cya...    »
 
Zeitschriftentitel:
Basic Res Cardiol 
Jahr:
2007 
Band / Volume:
102 
Heft / Issue:
Seitenangaben Beitrag:
224-32 
Sprache:
eng 
Print-ISSN:
0300-8428 
TUM Einrichtung:
r Kinderkardiologie und angeborene Herzfehler