Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Lenart, J; Dombrowski, F; Görlach, A; Kietzmann, T 
Titel:
Deficiency of manganese superoxide dismutase in hepatocytes disrupts zonated gene expression in mouse liver. 
Abstract:
The liver acinus displays a physiological periportal to perivenous oxygen gradient. This gradient was implicated to use reactive oxygen species (ROS) as mediators for the zonal gene expression. Mitochondria use oxygen and produce ROS, therefore they may contribute to the zonation of gene expression. To further elucidate this, we used the Cre-loxP system to generate a hepatocyte-specific null mutation of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) in mice. We found...    »
 
Zeitschriftentitel:
Arch Biochem Biophys 
Jahr:
2007 
Band / Volume:
462 
Heft / Issue:
Seitenangaben Beitrag:
238-44 
Sprache:
eng 
Print-ISSN:
0003-9861 
TUM Einrichtung:
r Kinderkardiologie und angeborene Herzfehler