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Document type:
journal article 
Author(s):
Lenart, J; Dombrowski, F; Görlach, A; Kietzmann, T 
Title:
Deficiency of manganese superoxide dismutase in hepatocytes disrupts zonated gene expression in mouse liver. 
Abstract:
The liver acinus displays a physiological periportal to perivenous oxygen gradient. This gradient was implicated to use reactive oxygen species (ROS) as mediators for the zonal gene expression. Mitochondria use oxygen and produce ROS, therefore they may contribute to the zonation of gene expression. To further elucidate this, we used the Cre-loxP system to generate a hepatocyte-specific null mutation of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) in mice. We found...    »
 
Journal title abbreviation:
Arch Biochem Biophys 
Year:
2007 
Journal volume:
462 
Journal issue:
Pages contribution:
238-44 
Language:
eng 
Print-ISSN:
0003-9861 
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler