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Document type:
journal article 
Author(s):
Flügel, D; Görlach, A; Michiels, C; Kietzmann, T 
Title:
Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner. 
Abstract:
Hypoxia-inducible transcription factor 1alpha (HIF-1alpha) is a key player in the response to hypoxia. Additionally, HIF-1alpha responds to growth factors and hormones which can act via protein kinase B (Akt). However, HIF-1alpha is not a direct substrate for this kinase. Therefore, we investigated whether the protein kinase B target glycogen synthase kinase 3 (GSK-3) may have an impact on HIF-1alpha. We found that the inhibition or depletion of GSK-3 induced HIF-1alpha whereas the overexpressio...    »
 
Journal title abbreviation:
Mol Cell Biol 
Year:
2007 
Journal volume:
27 
Journal issue:
Pages contribution:
3253-65 
Language:
eng 
Print-ISSN:
0270-7306 
TUM Institution:
r Kinderkardiologie und angeborene Herzfehler