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Dokumenttyp:
journal article 
Autor(en):
Belaiba, RS; Bonello, S; Zähringer, C; Schmidt, S; Hess, J; Kietzmann, T; Görlach, A 
Titel:
Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells. 
Abstract:
The oxygen sensitive alpha-subunit of the hypoxia-inducible factor-1 (HIF-1) is a major trigger of the cellular response to hypoxia. Although the posttranslational regulation of HIF-1alpha by hypoxia is well known, its transcriptional regulation by hypoxia is still under debate. We, therefore, investigated the regulation of HIF-1alpha mRNA in response to hypoxia in pulmonary artery smooth muscle cells. Hypoxia rapidly enhanced HIF-1alpha mRNA levels and HIF-1alpha promoter activity. Furthermore,...    »
 
Zeitschriftentitel:
Mol Biol Cell 
Jahr:
2007 
Band / Volume:
18 
Heft / Issue:
12 
Seitenangaben Beitrag:
4691-7 
Sprache:
eng 
Print-ISSN:
1059-1524 
TUM Einrichtung:
r Kinderkardiologie und angeborene Herzfehler