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Dokumenttyp:
journal article 
Autor(en):
Eichhorst, BF; Busch, R; Schweighofer, C; Wendtner, CM; Emmerich, B; Hallek, M; German CLL Study Group (GCLLSG) 
Titel:
Due to low infection rates no routine anti-infective prophylaxis is required in younger patients with chronic lymphocytic leukaemia during fludarabine-based first line therapy. 
Abstract:
The impact of the combination therapy fludarabine plus cyclophosphamide (FC) in comparison with fludarabine alone regarding the incidence and severity of infections among previously untreated patients with chronic lymphocytic leukaemia (CLL) was evaluated within a multicentre phase III study. A total of 375 patients, up to 65 years old, were randomised between fludarabine or FC for first line therapy. No routine anti-infective prophylaxis was provided. A total of 196 infectious episodes, includi...    »
 
Zeitschriftentitel:
Br J Haematol 
Jahr:
2007 
Band / Volume:
136 
Heft / Issue:
Seitenangaben Beitrag:
63-72 
Sprache:
eng 
Print-ISSN:
0007-1048 
TUM Einrichtung:
r Medizinische Statistik und Epidemiologie