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Dokumenttyp:
journal article 
Autor(en):
Conrad, H; Gebhard, K; Krönig, H; Neudorfer, J; Busch, DH; Peschel, C; Bernhard, H 
Titel:
ctls Directed against HER2 specifically cross-react with HER3 and HER4. 
Abstract:
The human epidermal growth factor receptor 2 (HER2) has been targeted as a breast cancer-associated Ag by T cell-based immunotherapeutical strategies such as cancer vaccines and adoptive T cell transfer. The prerequisite for a successful T cell-based therapy is the induction of T cells capable of recognizing the HER2-expressing tumor cells. In this study, we generated human cytotoxic T cell clones directed against the HER2(369-377) epitope known to be naturally presented with HLA-A*0201. Those H...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2008 
Band / Volume:
180 
Heft / Issue:
12 
Seitenangaben Beitrag:
8135-45 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; r Medizinische Mikrobiologie, Immunologie und Hygiene