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Document type:
journal article 
Author(s):
Ledran, MH; Krassowska, A; Armstrong, L; Dimmick, I; Renström, J; Lang, R; Yung, S; Santibanez-Coref, M; Dzierzak, E; Stojkovic, M; Oostendorp, RA; Forrester, L; Lako, M 
Title:
Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. 
Abstract:
Hematopoietic stem cells derived from human embryonic stem cells (hESCs) could provide a therapeutic alternative to bone marrow transplants, but the efficiency of currently available derivation protocols is low. In this study, we investigated whether coculture with monolayers of cells derived from mouse AGM and fetal liver, or with stromal cell lines derived from these tissues, can enhance hESC hematopoietic differentiation. We found that under such conditions hESC-derived differentiating cells...    »
 
Journal title abbreviation:
Cell Stem Cell 
Year:
2008 
Journal volume:
Journal issue:
Pages contribution:
85-98 
Language:
eng 
Print-ISSN:
1934-5909 
TUM Institution:
III. Medizinische Klinik und Poliklinik