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Document type:
journal article 
Author(s):
Bremm, A; Walch, A; Fuchs, M; Mages, J; Duyster, J; Keller, G; Hermannstädter, C; Becker, KF; Rauser, S; Langer, R; von Weyhern, CH; Höfler, H; Luber, B 
Title:
Enhanced activation of epidermal growth factor receptor caused by tumor-derived E-cadherin mutations. 
Abstract:
Mutations of the tumor suppressor E-cadherin and overexpression of the receptor tyrosine kinase epidermal growth factor receptor (EGFR) are among the most frequent genetic alterations associated with diffuse-type gastric carcinoma. Accumulating evidence suggests a functional relationship between E-cadherin and EGFR that regulates both proteins. We report that somatic mutation of E-cadherin is associated with increased activation of EGFR followed by enhanced recruitment of the downstream acting s...    »
 
Journal title abbreviation:
Cancer Res 
Year:
2008 
Journal volume:
68 
Journal issue:
Pages contribution:
707-14 
Language:
eng 
Print-ISSN:
0008-5472 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene; III. Medizinische Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie