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Document type:
journal article 
Author(s):
Ferch, U; zum Büschenfelde, CM; Gewies, A; Wegener, E; Rauser, S; Peschel, C; Krappmann, D; Ruland, J 
Title:
MALT1 directs B cell receptor-induced canonical nuclear factor-kappaB signaling selectively to the c-Rel subunit. 
Abstract:
NF-kappaB (Rel) transcription factors control physiological and pathological immune cell function. The scaffold proteins Bcl-10 and MALT1 couple antigen-receptor signals to the canonical NF-kappaB pathway and are pivotal in lymphomagenesis. Here we found that Bcl-10 and MALT1 differentially regulated B cell receptor-induced activation of RelA and c-Rel. Bcl-10 was essential for recruitment of the kinase IKK into lipid rafts for the activation of RelA and c-Rel, for blocking apoptosis and for ind...    »
 
Journal title abbreviation:
Nat Immunol 
Year:
2007 
Journal volume:
Journal issue:
Pages contribution:
984-91 
Language:
eng 
Print-ISSN:
1529-2908 
TUM Institution:
III. Medizinische Klinik und Poliklinik