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Dokumenttyp:
journal article 
Autor(en):
Peiffer, I; Eid, P; Barbet, R; Li, ML; Oostendorp, RA; Haydont, V; Monier, MN; Milon, L; Fortunel, N; Charbord, P; Tovey, M; Hatzfeld, J; Hatzfeld, A 
Titel:
A sub-population of high proliferative potential-quiescent human mesenchymal stem cells is under the reversible control of interferon alpha/beta. 
Abstract:
Type I interferon (IFN) is shown to control the reversible quiescence of a primitive human bone marrow mesenchymal stem cell (MSC) subpopulation. A 24 h pre-treatment of Stro1+/GlycoA- or CD45-/GlycoA- subpopulations with a monoclonal antibody (mAb) against the IFNAR1 chain of the human type I IFN receptor (64G12), or with a polyclonal anti-IFNalpha antibody, resulted in a marked increase in the number of very large colonies (CFU-F>3000 cells) obtained in the presence of low, but necessary, conc...    »
 
Zeitschriftentitel:
Leukemia 
Jahr:
2007 
Band / Volume:
21 
Heft / Issue:
Seitenangaben Beitrag:
714-24 
Sprache:
eng 
Print-ISSN:
0887-6924 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik