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Dokumenttyp:
journal article 
Autor(en):
Götze, KS; Hoffmann, D; Schätzl, HM; Peschel, C; Fend, F; Decker, T 
Titel:
Fatal Epstein-Barr virus-associated lymphoproliferative disorder following treatment with a novel mTOR inhibitor for relapsed chronic lymphocytic leukemia leukemia cells. 
Abstract:
We report on a patient with relapsed chronic lymphocytic leukemia (CLL) treated with the novel mTOR inhibitor RAD001 within a phase II clinical trial. Although the patient initially responded to therapy, RAD001 was discontinued after 32 weeks due to progression and fludarabine-based chemotherapy was started. The patient subsequently developed a rapidly fatal Epstein-Barr-virus-associated lymphoproliferative disorder, clonally unrelated to the CLL. The clinical course suggests caution when using...    »
 
Zeitschriftentitel:
Haematologica 
Jahr:
2007 
Band / Volume:
92 
Heft / Issue:
Seitenangaben Beitrag:
1282-3 
Sprache:
eng 
Print-ISSN:
0390-6078 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; r Virologie; r Allgemeine Pathologie und pathologische Anatomie