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Document type:
journal article 
Author(s):
Götze, KS; Hoffmann, D; Schätzl, HM; Peschel, C; Fend, F; Decker, T 
Title:
Fatal Epstein-Barr virus-associated lymphoproliferative disorder following treatment with a novel mTOR inhibitor for relapsed chronic lymphocytic leukemia leukemia cells. 
Abstract:
We report on a patient with relapsed chronic lymphocytic leukemia (CLL) treated with the novel mTOR inhibitor RAD001 within a phase II clinical trial. Although the patient initially responded to therapy, RAD001 was discontinued after 32 weeks due to progression and fludarabine-based chemotherapy was started. The patient subsequently developed a rapidly fatal Epstein-Barr-virus-associated lymphoproliferative disorder, clonally unrelated to the CLL. The clinical course suggests caution when using...    »
 
Journal title abbreviation:
Haematologica 
Year:
2007 
Journal volume:
92 
Journal issue:
Pages contribution:
1282-3 
Language:
eng 
Print-ISSN:
0390-6078 
TUM Institution:
III. Medizinische Klinik und Poliklinik; r Virologie; r Allgemeine Pathologie und pathologische Anatomie