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Dokumenttyp:
journal article 
Autor(en):
Nilsson, LM; Keller, UB; Yang, C; Nilsson, JA; Cleveland, JL; Roussel, MF 
Titel:
Ink4c is dispensable for tumor suppression in Myc-induced B-cell lymphomagenesis. 
Abstract:
p18(Ink4c) functions as a dedicated inhibitor of cyclin-D-dependent kinases. Loss of Ink4c predisposes mice to tumor development and, in a dose-dependent manner, complements the tumor-promoting effects of various oncogenes. We have now addressed whether Ink4c loss impacts B-cell tumor development in the Emu-Myc transgenic mouse, a model of human Burkitt lymphoma. Loss of one or both alleles did not influence the onset of lymphoma in Emu-Myc transgenics, and did not appreciably affect Myc's proli...    »
 
Zeitschriftentitel:
Oncogene 
Jahr:
2007 
Band / Volume:
26 
Heft / Issue:
20 
Seitenangaben Beitrag:
2833-9 
Sprache:
eng 
Print-ISSN:
0950-9232 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik