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Document type:
journal article 
Author(s):
Nilsson, LM; Keller, UB; Yang, C; Nilsson, JA; Cleveland, JL; Roussel, MF 
Title:
Ink4c is dispensable for tumor suppression in Myc-induced B-cell lymphomagenesis. 
Abstract:
p18(Ink4c) functions as a dedicated inhibitor of cyclin-D-dependent kinases. Loss of Ink4c predisposes mice to tumor development and, in a dose-dependent manner, complements the tumor-promoting effects of various oncogenes. We have now addressed whether Ink4c loss impacts B-cell tumor development in the Emu-Myc transgenic mouse, a model of human Burkitt lymphoma. Loss of one or both alleles did not influence the onset of lymphoma in Emu-Myc transgenics, and did not appreciably affect Myc's proli...    »
 
Journal title abbreviation:
Oncogene 
Year:
2007 
Journal volume:
26 
Journal issue:
20 
Pages contribution:
2833-9 
Language:
eng 
Print-ISSN:
0950-9232 
TUM Institution:
III. Medizinische Klinik und Poliklinik