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Document type:
journal article 
Author(s):
Zaph, C; Troy, AE; Taylor, BC; Berman-Booty, LD; Guild, KJ; Du, Y; Yost, EA; Gruber, AD; May, MJ; Greten, FR; Eckmann, L; Karin, M; Artis, D 
Title:
Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. 
Abstract:
Intestinal epithelial cells (IECs) provide a primary physical barrier against commensal and pathogenic microorganisms in the gastrointestinal (GI) tract, but the influence of IECs on the development and regulation of immunity to infection is unknown. Here we show that IEC-intrinsic IkappaB kinase (IKK)-beta-dependent gene expression is a critical regulator of responses of dendritic cells and CD4+ T cells in the GI tract. Mice with an IEC-specific deletion of IKK-beta show a reduced expression of...    »
 
Journal title abbreviation:
Nature 
Year:
2007 
Journal volume:
446 
Journal issue:
7135 
Pages contribution:
552-6 
Language:
eng 
Print-ISSN:
0028-0836 
TUM Institution:
II. Medizinische Klinik und Poliklinik