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Dokumenttyp:
journal article 
Autor(en):
Zaph, C; Troy, AE; Taylor, BC; Berman-Booty, LD; Guild, KJ; Du, Y; Yost, EA; Gruber, AD; May, MJ; Greten, FR; Eckmann, L; Karin, M; Artis, D 
Titel:
Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. 
Abstract:
Intestinal epithelial cells (IECs) provide a primary physical barrier against commensal and pathogenic microorganisms in the gastrointestinal (GI) tract, but the influence of IECs on the development and regulation of immunity to infection is unknown. Here we show that IEC-intrinsic IkappaB kinase (IKK)-beta-dependent gene expression is a critical regulator of responses of dendritic cells and CD4+ T cells in the GI tract. Mice with an IEC-specific deletion of IKK-beta show a reduced expression of...    »
 
Zeitschriftentitel:
Nature 
Jahr:
2007 
Band / Volume:
446 
Heft / Issue:
7135 
Seitenangaben Beitrag:
552-6 
Sprache:
eng 
Print-ISSN:
0028-0836 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik