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Document type:
journal article 
Author(s):
Reichert, M; Saur, D; Hamacher, R; Schmid, RM; Schneider, G 
Title:
Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells. 
Abstract:
The phosphoinositide-3-kinase (PI3K)/AKT signaling pathway controls fundamental processes of cancer cell biology like proliferation and cell survival. The PI3K/AKT pathway is activated in pancreatic ductal adenocarcinoma (PDAC) cells. The molecular mechanisms linking PI3K signaling to the cell cycle machinery in PDAC cells are not investigated in detail. Using the PI3K inhibitor Ly294002 as well as small interfering RNA targeting AKT1 expression, we show that PI3K controls the proliferation and...    »
 
Journal title abbreviation:
Cancer Res 
Year:
2007 
Journal volume:
67 
Journal issue:
Pages contribution:
4149-56 
Language:
eng 
Print-ISSN:
0008-5472 
TUM Institution:
II. Medizinische Klinik und Poliklinik