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Document type:
journal article 
Author(s):
Algül, H; Treiber, M; Lesina, M; Nakhai, H; Saur, D; Geisler, F; Pfeifer, A; Paxian, S; Schmid, RM 
Title:
Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis. 
Abstract:
Activation of the transcription factor NF-kappaB/Rel has been shown to be involved in inflammatory disease. Here we studied the role of RelA/p65, the main transactivating subunit, during acute pancreatitis using a Cre-loxP strategy. Selective truncation of the rela gene in pancreatic exocrine cells led to both severe injury of the acinar cells and systemic complications including lung and liver damage. Our data demonstrated that expression and induction of the protective pancreas-specific acute...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2007 
Journal volume:
117 
Journal issue:
Pages contribution:
1490-501 
Language:
eng 
Print-ISSN:
0021-9738 
TUM Institution:
II. Medizinische Klinik und Poliklinik