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Dokumenttyp:
journal article 
Autor(en):
Algül, H; Treiber, M; Lesina, M; Nakhai, H; Saur, D; Geisler, F; Pfeifer, A; Paxian, S; Schmid, RM 
Titel:
Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis. 
Abstract:
Activation of the transcription factor NF-kappaB/Rel has been shown to be involved in inflammatory disease. Here we studied the role of RelA/p65, the main transactivating subunit, during acute pancreatitis using a Cre-loxP strategy. Selective truncation of the rela gene in pancreatic exocrine cells led to both severe injury of the acinar cells and systemic complications including lung and liver damage. Our data demonstrated that expression and induction of the protective pancreas-specific acute...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2007 
Band / Volume:
117 
Heft / Issue:
Seitenangaben Beitrag:
1490-501 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik