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Document type:
journal article 
Author(s):
Siveke, JT; Einwächter, H; Sipos, B; Lubeseder-Martellato, C; Klöppel, G; Schmid, RM 
Title:
Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN. 
Abstract:
Growth factors have been implicated in pancreatic carcinogenesis. In this study we analyzed the effect of Tgfa overexpression in addition to mutant Kras(G12D) by crossing Elastase-Tgfa mice with p48(+/Cre); Kras(+/LSL-G12D) mice. We show that concomitant expression of TGFalpha and Kras(G12D) accelerates the progression of mPanIN lesions to metastatic pancreatic cancer and leads to the development of cystic papillary lesions resembling human intraductal papillary mucinous neoplasms (IPMN). Microa...    »
 
Journal title abbreviation:
Cancer Cell 
Year:
2007 
Journal volume:
12 
Journal issue:
Pages contribution:
266-79 
Language:
eng 
Print-ISSN:
1535-6108 
TUM Institution:
II. Medizinische Klinik und Poliklinik